8-Isoprostane as a Biomarker of Oxidative Stress in Interstitial Lung Diseases
作者： PAOLO MONTUSCHI , GIOVANNI CIABAT TONI , PAOLO PAREDI , PANAGIOTIS PANTELIDIS , ROLAND M. du BOIS
DOI: 10.1164/AJRCCM.158.5.9803102
关键词:
摘要: Oxidative stress contributes to the pathophysiology of interstitial lung diseases, such as cryptogenic fibrosing alveolitis (CFA), associated with systemic sclerosis (FASSc) and sarcoidosis. F2-isoprostanes are a series prostaglandin (PG) F2-like compounds produced in vivo independent cyclooxygenase, products radical-catalyzed lipid peroxidation. Measurement concentrations has proved be valuable assessing oxidative vivo. The aim this study was measure 8-epi-PGF2 α concentrations, one most abundant F2-isoprostane humans, bronchoalveolar lavage (BAL) normal subjects compare them those observed patients CFA (n = 9), FASSc 8) sarcoidosis 10). detectable BAL fluid (9.6 ± 0.8 pg/ml) its were increased approximately 5-fold (47.4 7.0, p < 0.001) (43.2 3.3, 0.001). also i...
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