Spheronization II: Drug Release from Drug-Diluent Mixtures

摘要: AbstractPellets were prepared from wet granulations using an extruder and spheronizer. Binary mixtures of active ingredient different types Avicel micro-crystalline cellulose products have been processed evaluated to determine the effect varying drug, diluent, drug-diluent ratio. Physical properties including in-vitro drug release profiles for uncoated pellets. Anhydrous Theophylline, USP Quinidine Sulfate, at ratios 10:90 80:20. Chlorpheniramine Maleate, Hydrochlorothiazide, incorporated into one system study influence more extreme values aqueous solubility on release. Drug was found vary with