L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.
作者： Fozard , M. Part , N. Prakash , J Grove , P. Schechter
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摘要: The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine decarboxylase activity associated with early embryogenesis mouse and arrests embryonic development at that stage. Contragestational effects were confirmed rat rabbit. An leads to a rapid putrescine concentration appears be essential during critical period after implantation for continued mammalian embryonal growth.
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