Dietary Supplementation with Vitamin E Reverses the Age-related Deficit in Long Term Potentiation in Dentate Gyrus

摘要: Abstract Long term potentiation (LTP) in dentate gyrus is impaired aged rats, and this has been associated with an age-related decrease membrane arachidonic acid concentration. In study, we considered whether the trigger for might be increased lipid peroxidation stimulated by proinflammatory cytokine, interleukin-1β. Groups of young rats were fed on a control diet or supplemented α-tocopherol assessed their ability to sustain LTP. Aged exhibited LTP analysis tissue prepared from these interleukin-1β, peroxidation, decreased concentration compared either diet. sustained manner indistinguishable increases interleukin-1β all reversed. We propose that may induces changes therefore responsible deficit long rats. The observation reverses consistent hypothesis some hippocampus derive oxidative stress.