Extracts from two frequently consumed spices — Cumin (Cuminum cyminum) and turmeric (Curcuma longa) — Inhibit platelet aggregation and alter eicosanoid biosynthesis in human blood platelets
作者： K.C. Srivastava
DOI: 10.1016/0952-3278(89)90187-7
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摘要: Abstract In the traditional Indian system of medicine, Ayurveda , several spices and herbs are claimed to possess medicinal properties, such as being antithrombotic, antiatherosclerotic, hypolipidemic, anti-inflammatory etc. Earlier we have reported that extracts from behave antiaggregatory agents inhibit eicosanoid synthesis. Similar studies with prepared cumin ( Cuminum cyminum ) turmeric Curcuma longa were undertaken. Ethereal extract both inhibited arachidonate-induced platelet aggregation. Extracts these thromboxane B 2 production exogenous 14 C) arachidonic acid (AA) in washed platelets; a simultaneous increase formation lipoxygenase-derived products was observed. Less T×B produced blood samples treated when they allowed clot. Turmeric incorporation C)AA into phospholipids deacylation AA-labelled on stimulation calcium ionophore A23187. Cumin devoid effects. two reduced C)T×B platelets challenged The property may, part, be explained by its effect biosynthesis.
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