Translational control of the circadian rhythm of liver sterol carrier protein.
作者： D M McGuire , C D Olson , H C Towle , M E Dempsey
DOI: 10.1016/S0021-9258(18)91014-8
关键词:
摘要: Abstract Rat liver sterol carrier protein (SCP), a major regulator of lipid metabolism and transport, undergoes rapid turnover dramatic circadian variation in amount. The level SCP was quantitated by specific immunochemical assay using an antibody to homogeneous SCP. During 12-h dark, light cycle, exhibits biphasic pattern level. A 7-fold increase (i.e. from 1 7 mg/g liver) occurs the dark period, peaking at midpoint returning basal levels beginning period. similar but smaller amount cycle. To elucidate basic mechanism responsible for these changes level, relative synthetic rate mRNA functional activity were measured during dark-light Alterations synthesis can account variations concentration. Although large occur rate, no significant found Therefore, rhythm does not reflect concentration SCP, instead is caused some controlling efficiency translation mRNA.
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