SU-G-IeP1-10: Permeability Evaluation of Interstitial Cystitis by DCE-MRI of the Bladder

摘要: Purpose: Interstitial cystitis (IC) is a chronic and painful condition that can lead to bladder pain syndrome (BPS) in women. IC BPS have been known manifest after physiological changes giving birth. In this project, we pioneered advanced new clinical utility using DCE-MRI assess permeability. At first IC/BPS perfusion methods were with ratio signal evaluation, now incorporate pharmacokinetics techniques allow for further assessment. Methods: In pilot study, female patients volunteers (IC=4, Control=3) underwent imaging GE 3T 750W MRI system. This project was approved by the OUHSC IRB. Multiple TR Images series acquired. analyzed coronal plane at 0-, 3-, 6-, 9-, 12-, 15-, 20-, 25-, 30-minute intervals. We used three-compartmental pharmacokinetic model these data. The compartments included: a) interior site of injection, b) wall, c) external psoas muscle. transformed corrected T1-relaxation based on multi-TR exponential regression before analysis. Results: Significant differences (p<0.05) detected relative means T1 concentration (IC/BPS=0.0107, control=0.616) outflow between k13 transfer coefficient, which represents injection leakage parenchyma. Trend (p<0.1) found permeability rim. also kurtosis histograms regional perfusion. No detectable reverse directions above (k21, k31). Conclusion: We report study. study illustrates early evidence possible tool detect measurement k13. These are intended advance quantitative IC/BPS, per goals/objectives Quantitative Imaging Biomarker Alliance (QIBA) other AAPM RSNA initiatives.