Transfusion-related acute lung injury following random donor platelet transfusion: a report of two cases.

摘要: Objectives: Transfusion-related acute lung injury (TRALI) following random donor platelet (RDP) transfusion is a rare complication of without any well-documented case reported in the English language literature. We describe 2 patients whom TRALI occurred RDP transfusion. Methods: Conventional clinical and laboratory methods. Results: Both developed shortness breath 30-60 min after completion required mechanical ventilatory support. Chest X-ray (CXR) both cases revealed bilateral pulmonary infiltrates. Patient 1 vasopressors for hypotension. Right heart catheterization ruled out fluid overload. remained hemodynamically stable. improved rapidly with continued respiratory support were extubated within 48 h. CXR at this time showed clearing In granulocyte antibody was identified plasma supporting diagnosis TRALI. Conclusions: suspected TRALI, HLA testing indicated recipients donors implicated components. Implicated need not be excluded from pool, but can used fractionated plasma-free