The PI3K Pathway in Colorectal Cancers

摘要: Phosphoinositide 3-kinase (PI3K) belongs to the intracellular lipid kinases family involved in diverse physiological processes, including proliferation, apoptosis, growth, and metabolism. Recent mutation analysis has shown that PI3K pathway is one of most frequently dysregulated pathways human cancer, colorectal cancer (CRC). Accordingly, significant effort been made develop pharmacological inhibitors targeting or key nodes this pathway, such as AKT mTOR. There are currently more than 20 unique compounds being assessed numerous cancer-related clinical trials. In addition, status cancers may have predictive prognostic implications. After 3 decades discovery PI3K, we now at an exciting intersection translating our knowledge signaling into developing effective therapeutics for treatment cancer. A comprehensive understanding circuits regulations essential rational development therapies. chapter, will discuss recent advances functions mutations pathogenesis CRC. We also review current drug-discovery efforts challenges