Cytogenetic analysis of epithelial renal‐cell tumors: Relationship with a new histopathological classification

摘要: Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes specific chromosomal abnormalities. In 1986, a new was proposed by Thoenes Storkel based on the cell type from which tumor arises. They distinguish S types: clear-cell, chromophilic, chromophobic, ductus Bellini oncocytic. Results of 105 primary tumors show that, in this classification, there is different renal-cell abnormalities at microscopic and/or molecular level. clear-cell compact structural aberrations chromosomes 1, 3, 4, 5q, 6, 10q, 11q 12q, together with polysomy X, 5, 7, 10, 12, 15, 16, 19, 20, 21 22, monosomy 8, 9, 13, 14, loss Y. main characteristics chromophilic tubulo-papillary trisomies 7 17, Y-chromosome. Chromophobic carcinoma seems to be correlated with, inter alia, 18, 11q, telomeric associations. Oncocytomas do not reveal any anomaly, except for trisomy 7. Loss heterozygosity 3p only found type. Some correlate particular grade tumor. These correlations support hypothesis that play role histogenesis oncogenesis RCC. may important diagnosis clinical prognosis. (C) 1993 Wiley-Liss, Inc.