Endotheliotropic elephant herpes virus (EEHV) infection. The first PCR-confirmed fatal case in Asia.

摘要: Since 1995, 4 suspected cases of Endotheliotropic Elephant Herpes Virus (EEHV) infection, i.e. based on clinical presentation, have occurred in Asia without resulting epidemic outbreaks as expected. In order to confirm the presence EEHV continent Asia, viral DNA particles from liver samples a wild-caught 3-year-old elephant found dead at Cambodian sanctuary and clinically diagnosed with EEHV, were PCR processed using known strain primers. The nucleic acids was confirmed had 99% sequence similarity U.S.A (gene bank locus: AF117265) 97% European AF354746) assigning this case EEHV-1 cluster. More than confirmation is phylogenic relationship USA strains no corresponding contact or transport elephants Asia. Thus, brings many traditional theories into question. Although almost forgotten, disease still ramped captive populations worldwide continues devastate particularly neonatal weaning-age population. Special attention continued research are needed specifically area basic virology epidemiology.