Memory of MEL cells to a previous exposure to inducer.
作者： Robert Levenson , David Housman
DOI: 10.1016/0092-8674(79)90256-3
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摘要: The mechanism of commitment murine erythroleukemia (MEL) cells to terminal differentiation has been examined. Before a significant proportion becomes committed, lag period at least 9 hr exposure inducer is observed. Cells withdrawn from can reinitiate without when reexposed. committed in culture discontinuously exposed identical that continuously even if withdrawal lasts for 18 hr. ability tolerate an interruption the termed "memory." memory previous complete up It partially erased after 36 and completely 72 length time persists not affected by initial inducer. These results suggest cellular component necessary event accumulates response this decay on order 10
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