A four-gene signature predicts disease progression in muscle invasive bladder cancer.

摘要: There are no reliable criteria to handle disease progression of muscle invasive bladder cancer (MIBC), which strongly influences patient survival. Therefore, an accurate predicting method identify progressive MIBC patients is greatly needed. The aim this study was a genetic signature associated with in MIBC. To address issue, we analyzed three independent cohorts (a training set, test set 1 and 2) comprising total 128 patients. Microarray gene expression profiling, including network analysis, performed the progression. prognostic value validated 2 by microarray real-time reverse transcriptase polymerase chain reaction (RT-PCR), respectively. determination patterns data analysis identified 1,320 genes Gene suggested that IL1B, S100A8, S100A9 EGFR were important mediators We putative four-gene two (log-rank test, P < 0.05 each, respectively) estimated predictive multivariate Cox regression (hazard ratio [HR], 6.24; 95% confidence interval [CI], 1.58-24.61; = 0.009). Finally, signature-based stratification demonstrated predictor In conclusion, molecular defined four represents promising diagnostic tool for identification at high risk