Evaluating anti-oxidant potential of ganoderic acid A in STAT 3 pathway in prostate cancer
作者： Balraj Singh Gill , Sanjeev Kumar , Navgeet
DOI: 10.1007/S11033-016-4074-Z
关键词:
摘要: Evaluating anti-oxidant potential of Ganoderic acid A in STAT 3 pathway Prostate cancer. Molecular docking and ADMET activities different isoforms ganoderic on were performed by Maestro 9.6 (Schrodinger Inc). The is best-docked among which analyses the expression level antioxidant PC-3 cells. receptor-based molecular reveals best binding interaction SH2 domain STAT3 with GScore (−6.134), kcal/mol, Lipophilic EvdW (−1.83), Electro (−1.1), Glide emodel (−31.857), H bond (1.98), MM-GBSA (−69.555). QikProp analyzed absorption, distribution, metabolism, excretion, toxicity (ADME/T). downregulates Moreover, inhibits proliferation, viability, ROS, DPPH, SOD1, SOD2, SOD3 Real time PCR a cell dose-dependent manner. revealed mechanistic signaling, ROS
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