Diabetic glucose dyshomeostasis and dyslipidemia in estrogen deficient rats: melatonin supplementation more potent than estrogen replacement therapy in alleviating the symptoms.
作者： Kauresh D Vachhrajani , Prem Kumar Singh , Darshee B Baxi , Ramachandran AV , None
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摘要: The present study was designed to evaluate the efficacy of melatonin supplementation as an alternative replacement therapy in estrogen deficient diabetic rats. Ovariectomized Wistar rats were treated with estrogen/progesterone, melatonin, or a combination both and melatonin. Various parameters glucoregulation (serum glucose, insulin, GTT, IRT, tissue glycogen enzymes carbohydrate metabolism) serum lipids analyzed all experimental groups indicated administration alone at low dose be most effective reversing changes. higher relatively greater value regulating dyslipidemia, although lower potent ameliorating glycemic dysregulation. thereby provided evidence for potential ERT subjects.
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