Triblock poly(lactic acid)‐b‐poly(ethylene glycol)‐b‐poly(lactic acid)/paclitaxel conjugates: Synthesis, micellization, and cytotoxicity
作者： Zhigang Xie , Tiancheng Lu , Xuesi Chen , Changhai Lu , Yonghui Zheng
DOI: 10.1002/APP.26236
关键词:
摘要: A triblock poly(lactic acid)-b-poly(ethylene glycol)-b-poly(lactic acid) (PLA-PEG-PLA)/paclitaxel (PTX) conjugate was synthesized by the reaction of carboxyl-terminated copolymer PLA-PEG-PLA with PTX in presence dicyclohexylcarbodiimide and dimethylaminopyridine. Carboxyl-terminated prepared hydroxyl end groups succinic anhydride. Its structure confirmed NMR gel permeation chromatography. The PLA-PEG-PLA/PTX conjugates could self-assemble into micelles aqueous solutions a low critical micelle concentration. Dynamic light scattering environmental scanning electron microscopy analyses revealed their spherical size 220 nm. antitumor activity against woman Hela cancer cells, evaluated 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrazolium bromide method, showed that had an similar to pure PTX. obtained are expected be used clinical practice.
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core.ac.uk 参考文章(29)
E A Eisenhauer, W W ten Bokkel Huinink, K D Swenerton, L Gianni, J Myles, M E van der Burg, I Kerr, J B Vermorken, K Buser, N Colombo, European-Canadian randomized trial of paclitaxel in relapsed ovarian cancer: high-dose versus low-dose and long versus short infusion. Journal of Clinical Oncology. ,vol. 12, pp. 2654- 2666 ,(1994) , 10.1200/JCO.1994.12.12.2654
Zhiping Zhang, Si-Shen Feng, The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly(lactide)–tocopheryl polyethylene glycol succinate nanoparticles Biomaterials. ,vol. 27, pp. 4025- 4033 ,(2006) , 10.1016/J.BIOMATERIALS.2006.03.006
Chau-Hui Wang, Ging-Ho Hsiue, Polymer-DNA hybrid nanoparticles based on folate-polyethylenimine-block-poly(L-lactide) Bioconjugate Chemistry. ,vol. 16, pp. 391- 396 ,(2005) , 10.1021/BC049754J
Kiyotaka Tsuchiya, Tatsuya Uchida, Mikio Kobayashi, Hiroshi Maeda, Toshimitsu Konno, Hidetoshi Yamanaka, Tumor-targeted chemotherapy with SMANCS in lipiodol for renal cell carcinoma: longer survival with larger size tumors Urology. ,vol. 55, pp. 495- 500 ,(2000) , 10.1016/S0090-4295(99)00537-3
Oju Jeon, Soo-Hong Lee, Soo Hyun Kim, Young Moo Lee, Young Ha Kim, Synthesis and Characterization of Poly(l-lactide)−Poly(ε-caprolactone) Multiblock Copolymers Macromolecules. ,vol. 36, pp. 5585- 5592 ,(2003) , 10.1021/MA034006V
Kazunori Emoto, Yukio Nagasaki, Kazunori Kataoka, A Core−Shell Structured Hydrogel Thin Layer on Surfaces by Lamination of a Poly(ethylene glycol)-b-poly(d,l-lactide) Micelle and Polyallylamine Langmuir. ,vol. 16, pp. 5738- 5742 ,(2000) , 10.1021/LA9914514
Kenji Yasugi, Teruo Nakamura, Yukio Nagasaki, Masao Kato, Kazunori Kataoka, Sugar-Installed Polymer Micelles: Synthesis and Micellization of Poly(ethylene glycol)−Poly(d,l-lactide) Block Copolymers Having Sugar Groups at the PEG Chain End Macromolecules. ,vol. 32, pp. 8024- 8032 ,(1999) , 10.1021/MA991066L
Xiaoqing Cai, Na Wang, Xianfu Lin, CHEMO-ENZYMATIC SYNTHESIS OF OPTICALLY ACTIVE POLYMERIC PRODRUG OF NAPROXEN, KETOPROFEN AND IBUPROFEN Polymer. ,vol. 47, pp. 6491- 6495 ,(2006) , 10.1016/J.POLYMER.2006.06.043
A H Thomson, P A Vasey, L S Murray, J Cassidy, D Fraier, E Frigerio, C Twelves, Population pharmacokinetics in phase I drug development: a phase I study of PK1 in patients with solid tumours. British Journal of Cancer. ,vol. 81, pp. 99- 107 ,(1999) , 10.1038/SJ.BJC.6690657
Xuefei Zhang, Yuxin Li, Xuesi Chen, Xiuhong Wang, Xiaoyi Xu, Qizhi Liang, Junli Hu, Xiabin Jing, Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate. Biomaterials. ,vol. 26, pp. 2121- 2128 ,(2005) , 10.1016/J.BIOMATERIALS.2004.06.024