Racial (black-white) differences in insulin secretion and clearance in adolescents: the Bogalusa heart study.

摘要: Objective. Earlier we found black-white contrast in insulin levels adolescents. The purpose of this study is to assess whether difference attributable alterations secretion and/or clearance. Methods. Fasting circulating and C-peptide concentrations were examined 1157 adolescents aged 11 18 years from a biracial community. plasma C-peptide, ratio, glucose ratio used as indices secretion, hepatic clearance, sensitivity, respectively. Results. After adjusting several covariates (age, sexual maturation, obesity), black had higher (14.99 vs 12.66 µU/mL girls). However, they lower than their white counterparts, indicating by pancreatic beta cells Moreover, (0.14 0.17), suggesting reduced clearance In addition, significantly girls suggest sensitivity group. Further, differences between disappeared after for ratio. Conclusion. These data that elevated observed adolescents, especially girls, may be attributed decreased not hypersecretion insulin.