The developing Drosophila eye - a new model to study centriole reduction.

摘要: In the developing Drosophila eye, centrioles of differentiating retinal cells are not surrounded by microtubule-nucleating γ-tubulin, suggesting that they unable to organize functional microtubule-organizing centers. Consistent with this idea, Cnn and Spd-2, which involved in γ-tubulin recruitment, scaffold protein Plp, plays a role organization pericentriolar material, lost third-instar larval stage. However, maintain their structural integrity, both parent accumulate Asl Ana1. Although loading points acquisition motherhood condition, daughter fail recruit Plk4 do duplicate. it is surprising mother also never This suggests sufficient, system, allow centriole duplication. By halfway through pupal life, number decreases defects, ranging from being incomplete or lacking B-tubules, detected. Asl, Ana1 Sas-4 still present, integrity does depend on these proteins.