Effects of leptin on fasting-induced inhibition of neuronal nitric oxide synthase mRNA in the paraventricular and supraoptic nuclei of rats
作者： Toyohi Isse , Yoichi Ueta , Ryota Serino , Jun Noguchi , Yukiyo Yamamoto
DOI: 10.1016/S0006-8993(99)02065-X
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摘要: Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA the paraventricular nucleus (PVN) and supraoptic (SON) of rats. The effect intracerebroventricular (i.c.v.) administration leptin on nNOS level PVN SON fasting rats was studied by situ hybridization histochemistry. Leptin (10 μg/kg b.wt) or vehicle administered i.c.v. at 1700 h two successive days for 2 days. with significant SON. Central prevented fasting-induced Administration also reductions thyrotropin-releasing hormone (TRH) corticotropin-releasing (CRH) mRNAs parvocellular division PVN. These results suggest that is associated as well TRH CRH
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sci-hub.se 参考文章(42)
Marie-Louise Håkansson, Hilary Brown, Nico Ghilardi, Radek C. Skoda, Björn Meister, LEPTIN RECEPTOR IMMUNOREACTIVITY IN CHEMICALLY DEFINED TARGET NEURONS OF THE HYPOTHALAMUS The Journal of Neuroscience. ,vol. 18, pp. 559- 572 ,(1998) , 10.1523/JNEUROSCI.18-01-00559.1998
Peter Kristensen, Martin E. Judge, Lars Thim, Ulla Ribel, Kennet N. Christjansen, Birgitte S. Wulff, Jes T. Clausen, Per B. Jensen, Ole D. Madsen, Niels Vrang, Philip J. Larsen, Sven Hastrup, Hypothalamic CART is a new anorectic peptide regulated by leptin Nature. ,vol. 393, pp. 72- 76 ,(1998) , 10.1038/29993
Marta E Couce, Bartolome Burguera, Joseph E Parisi, Michael D Jensen, Ricardo V Lloyd, None, Localization of Leptin Receptor in the Human Brain Neuroendocrinology. ,vol. 66, pp. 145- 150 ,(1997) , 10.1159/000127232
N. G. Blake, M. R. Johnson, D. J. A. Eckland, O. J. F. Foster, S. L. Lightman, Effect of food deprivation and altered thyroid status on the hypothalamic-pituitary-thyroid axis in the rat. Journal of Endocrinology. ,vol. 133, pp. 183- 188 ,(1992) , 10.1677/JOE.0.1330183
Abhiram Sahu, Evidence Suggesting That Galanin (GAL), Melanin-Concentrating Hormone (MCH), Neurotensin (NT), Proopiomelanocortin (POMC) and Neuropeptide Y (NPY) Are Targets of Leptin Signaling in the Hypothalamus Endocrinology. ,vol. 139, pp. 795- 798 ,(1998) , 10.1210/ENDO.139.2.5909
Shuso Suemaru, Kozo Hashimoto, Teruhiko Hattori, Hiroshi Inoue, Jingo Kageyama, Zensuke Ota, Starvation-induced changes in rat brain corticotropin-releasing factor (CRF) and putuitary-adrenocortical response Life Sciences. ,vol. 39, pp. 1161- 1166 ,(1986) , 10.1016/0024-3205(86)90347-4
John E. Morley, James F. Flood, Competitive antagonism of nitric oxide synthetase causes weight loss in mice Life Sciences. ,vol. 51, pp. 1285- 1289 ,(1992) , 10.1016/0024-3205(92)90018-K
Yiying Zhang, Ricardo Proenca, Margherita Maffei, Marisa Barone, Lori Leopold, Jeffrey M. Friedman, Positional cloning of the mouse obese gene and its human homologue Nature. ,vol. 372, pp. 425- 432 ,(1994) , 10.1038/372425A0
Jeffrey D. White, Maryann Kershaw, Increased hypothalamic neuropeptide Y expression following food deprivation. Molecular and Cellular Neuroscience. ,vol. 1, pp. 41- 48 ,(1990) , 10.1016/1044-7431(90)90040-B
R. Seeley, G. van Dijk, L. Campfield, F. Smith, P. Burn, J. Nelligan, S. Bell, D. Baskin, S. Woods, M. Schwartz, Intraventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Hormone and Metabolic Research. ,vol. 28, pp. 664- 668 ,(1996) , 10.1055/S-2007-979874