The prevalence, severity, and impact of opioid-induced bowel dysfunction: results of a US and European Patient Survey (PROBE 1)

摘要: Objective.  This multinational, Internet-based survey was designed to assess the prevalence, frequency, severity, and impact of opioid-induced bowel dysfunction (OBD) in patients receiving opioid therapy for chronic pain taking laxatives. Design.  In total, 322 daily oral opioids laxatives completed 45-item questionnaire. At time survey, 45% reported <3 movements per week. The most prevalent side effects were constipation (81%) straining pass a movement (58%). Those considered bothersome by (in order rank) constipation, straining, fatigue, small or hard movements, insomnia. Results.  Most OBD symptoms specified questionnaire experienced majority ≥4 times Constipation symptom that often as severe. their had at least moderate negative on overall quality life activities living. A third missed, decreased stopped using make it easier have movement. Conclusion.  findings confirm occurs frequently, despite use laxatives, individuals pain. These gastrointestinal add burden already patients, negatively impacting and, some cases, affecting treatment itself.