Discrete region of the insulin receptor carboxyl terminus plays key role in insulin action.
作者： Michel Bernier , Hemanta K. Kole , Chahrzad Montrose-Rafizadeh , Sutapa Kole
DOI: 10.1002/(SICI)1097-4644(20000701)78:1<160::AID-JCB15>3.0.CO;2-G
关键词:
摘要: In the present study, we attempted to determine importance of a 23-amino-acid sequence within carboxyl terminus human insulin receptor (IR) molecule in modulating action Chinese hamster ovary cells. Stable expression minigene encoding fragment led an increase insulin-induced IR autophosphorylation that was 2.4-fold higher when compared IR-expressing cells transfected with empty vector. Insulin-stimulated downstream signaling also significantly elevated expressing minigene. It found had no effect toward insulin-like growth factor I kinase activity and function. These results indicate contains motif acts as physiologic modulator signaling. J. Cell. Biochem. 78:160-169, 2000. Published 2000 Wiley-Liss, Inc.
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