Spectral editing in proton magnetic resonance spectroscopy. Determination of GABA level in the brains of humans with ultra-high risk for schizophrenia
作者： P. E. Men’shchikov , N. A. Semenova , M. V. Ublinskii , T. A. Akhadov , R. A. Keshishyan
DOI: 10.1007/S11172-015-1144-7
关键词:
摘要: The intravital level of γ-aminobutyric acid (GABA) was measured for the first time and imbalance key excitatory inhibitory neurotransmitters in brain frontal lobes patients with ultra-high risk schizophrenia studied. proton magnetic resonance spectroscopy (1H MRS) MEGA-PRESS pulse sequence separating superimposed signals used. area interest anterior cingulate cortex account lateralization right left hemispheres. A statistically significant decrease GABA concentration (by 25%) [GABA]/[GLX] ratio (GLX is glutamate + glutamine) 20%) were found hemisphere, this hemisphere remaining at normal level.
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