New purine alkaloids from the Red Sea marine tunicate Symplegma rubra
作者： Diaa T.A. Youssef , Gamal A. Mohamed , Lamiaa A. Shaala , Jihan M. Badr , Faida H. Bamanie
DOI: 10.1016/J.PHYTOL.2015.06.012
关键词:
摘要: Abstract Investigation of the Red Sea marine tunicate Symplegma rubra Monniot, 1972 gave three new purine alkaloids namely 6-methoxy-7,9-dimethyl-8-oxoguanine ( 1 ), 6-methoxy-9-methyl-8-oxoguanine 2 and 2-methoxy-7-methyl-8-oxoadenine 4 ) together with seven known compounds: 6-methoxy-7-methyl-8-oxoguanine 3 9-methyl-8-oxoadenine 5 7-methyl-8-oxoadenine 6 8-oxoadenine 7 3-methylxanthine 8 inosine 9 homarine (pyridinium-2-carboxylic acid-1-methyl) 10 ). Compound was reported here for first time from a natural source. The structure determination compounds accomplished by extensive interpretation their spectroscopic data including 1D H 13 C) 2D H– COSY, HSQC, HMBC) NMR high-resolution mass spectral data. isolated were evaluated protein kinase inhibitory activity against different kinases (CDK5, CK1, DyrK1A, GSK3) at 10 μg/mL. showed moderate these kinases.
elsevier.com
sci-hub.se 参考文章(28)
Taisuke ITAYA, Yasutaka TAKADA, Tae KANAI, Tozo FUJII, Purines. LXXIV. Syntheses and rearrangements of 8-oxoadenines monomethylated at the N6-, 1-, and 3-positions Chemical & Pharmaceutical Bulletin. ,vol. 44, pp. 2318- 2321 ,(1996) , 10.1248/CPB.44.2318
Claire C. Chehade, Ricardo L. A. Dias, Roberto G. S. Berlinck, Antonio G. Ferreira, Letícia V. Costa, Marisa Rangel, Elena L. A. Malpezzi, José Carlos de Freitas, Eduardo Hajdu, 1,3-Dimethylisoguanine, a new purine from the marine sponge Amphimedon viridis. Journal of Natural Products. ,vol. 60, pp. 729- 731 ,(1997) , 10.1021/NP970021F
Raphaël Frédérick, Céline Bruyère, Christelle Vancraeynest, Jérémy Reniers, Céline Meinguet, Lionel Pochet, Anders Backlund, Bernard Masereel, Robert Kiss, Johan Wouters, Novel trisubstituted harmine derivatives with original in vitro anticancer activity Journal of Medicinal Chemistry. ,vol. 55, pp. 6489- 6501 ,(2012) , 10.1021/JM300542E
Byoungho Moon, Bill J. Baker, James B. McClintock, Purine and nucleoside metabolites from the Antarctic sponge Isodictya erinacea. Journal of Natural Products. ,vol. 61, pp. 116- 118 ,(1998) , 10.1021/NP970358H
Mansour Debdab, François Carreaux, Steven Renault, Meera Soundararajan, Oleg Fedorov, Panagis Filippakopoulos, Olivier Lozach, Lucie Babault, Tania Tahtouh, Blandine Baratte, Yasushi Ogawa, Masatoshi Hagiwara, Andreas Eisenreich, Ursula Rauch, Stefan Knapp, Laurent Meijer, Jean-Pierre Bazureau, Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing Journal of Medicinal Chemistry. ,vol. 54, pp. 4172- 4186 ,(2011) , 10.1021/JM200274D
K Patel, M Gadewar, R Tripathi, SK Prasad, Dinesh Kumar Patel, A review on medicinal importance, pharmacological activity and bioanalytical aspects of beta-carboline alkaloid “Harmine” Asian pacific Journal of Tropical Biomedicine. ,vol. 2, pp. 660- 664 ,(2012) , 10.1016/S2221-1691(12)60116-6
Hisaaki Yagi, Shigeki Matsunaga, Nobuhiro Fusetanix, Isolation of 1-Methylherbipoline, a Purine Base, from a Marine Sponge, Jaspis sp. Journal of Natural Products. ,vol. 57, pp. 837- 838 ,(1994) , 10.1021/NP50108A025
Aline Primot, Blandine Baratte, Marie Gompel, Annie Borgne, Sylvie Liabeuf, Jean-Louis Romette, Eek-hoon Jho, Frank Costantini, Laurent Meijer, None, Purification of GSK-3 by Affinity Chromatography on Immobilized Axin Protein Expression and Purification. ,vol. 20, pp. 394- 404 ,(2000) , 10.1006/PREP.2000.1321
Jens Reinhardt, Yoan Ferandin, Laurent Meijer, Purification of CK1 by affinity chromatography on immobilised axin. Protein Expression and Purification. ,vol. 54, pp. 101- 109 ,(2007) , 10.1016/J.PEP.2007.02.020
Scott S. Mitchell, Andy B. Whitehill, Henry G. Trapido-Rosenthal, Chris M. Ireland, Isolation and characterization of 1,3-dimethylisoguanine from the Bermudian sponge Amphimedon viridis Journal of Natural Products. ,vol. 60, pp. 727- 728 ,(1997) , 10.1021/NP970015J