Manipulation of Pharmaceutical Polymorphic Transformation Process Using Excipients
作者： Beiqian Tian , Zhiyong Ding , Shuyi Zong , Jinyue Yang , Na Wang
DOI: 10.2174/1381612826666200213122302
关键词:
摘要: BACKGROUND In the pharmaceutical field, it is vital to ensure a consistent product containing single solid-state form of active ingredient (API) in drug product. However, some APIs are suffering from risk transformation their target forms during processing, formulation and storage. METHODS The purpose this review summarize relevant category excipients demonstrate availability importance using as key strategy manipulate polymorphic transformation. RESULTS excipient effects on solvent-mediated phase transformations, transitions amorphous crystallization significant. Common including amino acids derivatives, surfactants, various polymers different manipulation were summarized discussed. CONCLUSION Appropriate use plays role manipulating process corresponding APIs, with promising application guaranteeing stability effectiveness dosage forms.
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