Role and Regulation of Proteases in Human Glioma

摘要: The invasive and destructive characteristics of malignant neoplasms in the central nervous system are great clinical importance, as they contribute to a poor prognosis. Patients diagnosed with glioblastomas have mean survival only 8-12 months following surgery, chemotherapy or radiation therapy. infiltrative growth pattern gliomas contrasts that brain metastases, which most often grow self-defined borders adjacent neural tissue. Whereas, unregulated proliferation primary tumor cells within skull is major factor prognosis afflicted patients, ability neoplastic migrate invade surrounding normal tissue presents hurdle successful therapeutic intervention. Brain invasion complex phenomenon, involves interaction between cells, stromal extracellular matrix (ECM). Proteolytic modification ECM leads cell migration into (Edwards et al 1998; Quaranta 2000; Werb 1999). degradation processes involve highly organized interplay proteases their cellular binding sites well specific substrates internalization receptors. Proteases been known be critically involved number steps progression, such growth, invasion, metastasis (Koblinski 2000). Members cysteine proteinase, serine proteinase metalloproteinase superfamilies play functional roles proteins (Rooprai 1997).