B0 and B1-insensitive uniform T1-weighting for quantitative, first-pass myocardial perfusion magnetic resonance imaging†

摘要: Myocardial perfusion can be estimated, in principle, from first-pass MR images by converting the T 1 -weighted signal-time curves to contrast agent concentration-time curves. Typically, weighting is achieved saturating magnetization with a nonselective radiofrequency (RF) pulse prior imaging sequence. The accuracy of estimate derived single-point signal depends on initial residual longitudinal (RLM) produced saturation pulse. In this study we demonstrate that single-shot, echo-planar used show RLM resulting incomplete due static magnetic field and RF inhomogeneities heart at 1.5 T. Three pulses, single, composite simple, B -insensitive rotation (BIR-4) were evaluated phantom cardiac experiments. image was calculated normalizing saturated proton-density-weighted image. Mean three pulses significantly different noncontrast (RLM s i n g l e = 0.108 ′ 0.078; c o m p t 0.051 0.052; I R - 4 0.011 0.009; P < 0.001; 20). Using BIR-4 perform seems promising for improving effectiveness uniformity imaging.