Gluconic acid production by Aspergillus terreus

摘要: Aim: Aspergillus terreus produces itaconic acid at low pH but lovastatin and other secondary metabolites higher in the fermentation. The utilization of glucose as a carbon substrate was investigated for metabolite production by A. terreus. Methods Results:  With starting 6·5, rapidly metabolized to gluconic wild-type strain transformants harbouring Aspergillus niger genes encoding 6-phosphofructo-1-kinases with superior kinetic regulatory properties bioproduction from glucose. On exhaustion batch fermentations, accumulated utilized source. Conclusions:  A novel pathway catabolism demonstrated A. terreus, species whose wild type is, without any development, capable producing high molar conversion efficiency (up 0·7 mol mol−1 consumed). Significance Impact Study: Aspergillus is potential producer organism acid, compound many uses bulk chemical. new knowledge fermentation strategies can be devised feeding using feedback regulation pH.