17-AAG sensitized malignant glioma cells to death-receptor mediated apoptosis.
作者： Markus David Siegelin , Antje Habel , Timo Gaiser
DOI: 10.1016/J.NBD.2008.10.005
关键词:
摘要: 17-AAG is a selective HSP90-inhibitor that exhibited therapeutic activity in cancer. In this study three glioblastoma cell lines (U87, LN229 and U251) were treated with 17-AAG, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or the combination of both. Treatment subtoxic doses induces rapid apoptosis TRAIL-resistant glioma cells, suggesting combined treatment may offer an attractive strategy for treating gliomas. down-regulated survivin through proteasomal degradation. addition, over-expression attenuated cytotoxicity induced by TRAIL. summary, key regulator TRAIL-17-AAG mediated death malignant glioma.
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