Multiple Fibroblast Phenotypes in Cancer Patients: Heterogeneity in Expression of Migration Stimulating Factor
作者： Ana M. Schor , Seth L. Schor
DOI: 10.1007/978-94-007-0659-0_11
关键词:
摘要: Migration Stimulating Factor (MSF) is an oncofetal regulatory molecule, constitutively expressed by various cell types during fetal development, generally not their counterparts in healthy adult tissues, but re-expressed cancer progression. The diverse bioactivities of MSF, including its potent stimulation migration/invasion, matrix remodelling and angiogenesis, suggest that it makes a significant contribution to driving tumour In this review, we discuss the role MSF within general perspective perturbed cell-fibroblast interactions pathogenesis potential utility as novel clinical target for improved patient management.
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