Nongenomic signaling pathways of estrogen toxicity.

摘要: Xenoestrogens can affect the healthy functioning of a variety tissues by acting as potent estrogens via nongenomic signaling pathways or interfering with those actions multiple physiological estrogens. Collectively, our and other studies have compared wide range estrogenic compounds, including some closely structurally related subgroups. The that been studied include environmental contaminants different subclasses, dietary estrogens, several prominent metabolites. By comparing functional responses to these we begun address structural requirements for their through membrane estrogen receptors in pituitary, comparison tissues, gain insights into typical non-monotonic dose-response behavior. Their inputs cellular begin processes eventually integrate at level mitogen-activated protein kinase activities coordinately regulate broad destinies, such proliferation, apoptosis, differentiation.