HER2 Status in Premalignant, Early, and Advanced Neoplastic Lesions of the Stomach

摘要: Objectives. HER2 expression in gastric cancer (GC) has received attention as a potential target for therapy with Trastuzumab. We reviewed the current knowledge on status premalignant lesions and early (EGC) advanced (AGC) GC to discuss possible pathogenetic prognostic roles of overexpression GC. Results. was documented low-grade (LG) high-grade intraepithelial neoplasia (HG-IEN), higher frequency type dysplasia. significantly associated disease recurrence poor prognosis EGC representing an independent risk factor lymph node metastases. more frequent AGC characterized by high grade, stage, Ki-67 labeling index. The discordance evidenced between primitive synchronous or metachronous Conclusions. suggests its involvement steps carcinogenesis. assessment may be helpful identification patients who are at low developing nodal Finally, primary metastases support routine both metastatic lesions.