Tubular injury and cell-cycle arrest biomarkers to predict acute kidney injury in noncritically ill children receiving aminoglycosides.
作者： Hayton Chui , Jillian Caldwell , Mariya Yordanova , Vedran Cockovski , Daniel Fredric
关键词:
摘要: Aim: NGAL, IL-18, KIM-1 as well urinary TIMP2 and IGFBP7 their mathematical product (TIMP2*IGFBP7) were evaluated for detecting pediatric aminoglycoside acute kidney injury (AG-AKI). Methods: In a prospective study, noncritically ill children received aminoglycosides (AG) ≥3 days. The area under the curve (AUC) biomarkers to detect AKI was calculated by a) days before onset; b) treatment Results: There 113 AG episodes (68% febrile neutropenia). group had higher proportion with neutropenia. significantly lower NGAL 3 AKI, patients neutropenia during (p < 0.05). IL-18 TIMP2*IGFBP7 AUC ≥0.73 at 3, 2 onset. Conclusion: modest early of AG-AKI. Febrile associated NGAL.
sci-hub.st 参考文章(42)
Meredith P. Schuh, Edward Nehus, Qing Ma, Christopher Haffner, Michael Bennett, Catherine D. Krawczeski, Prasad Devarajan, Long-term Stability of Urinary Biomarkers of Acute Kidney Injury in Children American Journal of Kidney Diseases. ,vol. 67, pp. 56- 61 ,(2016) , 10.1053/J.AJKD.2015.04.040
Diana Jansen, Esther Peters, Suzanne Heemskerk, Linda Koster-Kamphuis, Martijn Bouw, Hennie Roelofs, Wim van Oeveren, Arno van Heijst, Peter Pickkers, Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit. American Journal of Perinatology. ,vol. 33, pp. 180- 187 ,(2015) , 10.1055/S-0035-1563714
Patrick T. Murray, Ravindra L. Mehta, Andrew Shaw, Claudio Ronco, Zoltan Endre, John A. Kellum, Lakhmir S. Chawla, Dinna Cruz, Can Ince, Mark D. Okusa, Potential use of biomarkers in acute kidney injury: report and summary of recommendations from the 10th Acute Dialysis Quality Initiative consensus conference Kidney International. ,vol. 85, pp. 513- 521 ,(2014) , 10.1038/KI.2013.374
Nikki Rink, Michael Zappitelli, Estimation of glomerular filtration rate with and without height: effect of age and renal function level Pediatric Nephrology. ,vol. 30, pp. 1327- 1336 ,(2015) , 10.1007/S00467-015-3063-0
Shina Menon, Eric S. Kirkendall, Hovi Nguyen, Stuart L. Goldstein, Acute Kidney Injury Associated with High Nephrotoxic Medication Exposure Leads to Chronic Kidney Disease after 6 Months The Journal of Pediatrics. ,vol. 165, pp. 522- 527.e2 ,(2014) , 10.1016/J.JPEDS.2014.04.058
Melanie Meersch, Christoph Schmidt, Hugo Van Aken, Jan Rossaint, Dennis Görlich, Dirk Stege, Edward Malec, Katarzyna Januszewska, Alexander Zarbock, Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury after Pediatric Cardiac Surgery PLoS ONE. ,vol. 9, pp. e110865- ,(2014) , 10.1371/JOURNAL.PONE.0110865
John M Arthur, Elizabeth G Hill, Joseph L Alge, Evelyn C Lewis, Benjamin A Neely, Michael G Janech, James A Tumlin, Lakhmir S Chawla, Andrew D Shaw, SAKInet Investigators, Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery Kidney International. ,vol. 85, pp. 431- 438 ,(2014) , 10.1038/KI.2013.333
Rodrigo Cartin-Ceba, Bekele Afessa, Ognjen Gajic, Low baseline serum creatinine concentration predicts mortality in critically ill patients independent of body mass index* Critical Care Medicine. ,vol. 35, pp. 2420- 2423 ,(2007) , 10.1097/01.CCM.0000281856.78526.F4
Kelly Benisty, Michael Zappitelli, Measures of GFR in Health and Disease Current Pediatrics Reports. ,vol. 3, pp. 101- 110 ,(2015) , 10.1007/S40124-014-0067-3
Alain Vandewalle, Nicolette Farman, Jean-Paul Morin, Jean-Paul Fillastre, Pierre-Yves Hatt, Jean-Paul Bonvalet, with the technical assistance of M. Gastineau, F. Wanstok, Gentamicin incorporation along the nephron: Autoradiographic study on isolated tubules Kidney International. ,vol. 19, pp. 529- 539 ,(1981) , 10.1038/KI.1981.50