Voluntary Exercise Prevents Oxidative Stress in the Brain of Phenylketonuria Mice

作者: Priscila Nicolao Mazzola , Vibeke Bruinenberg , Karen Anjema , Danique van Vliet , Carlos Severo Dutra-Filho

DOI: 10.1007/8904_2015_498

关键词:

摘要: Background: High phenylalanine levels in phenylketonuria (PKU) have been associated with brain oxidative stress and amino acid imbalance. Exercise has shown to improve function hyperphenylalaninemia neurodegenerative diseases. This study aimed verify the effects of exercise on coordination balance, plasma levels, markers PKU mice.

参考文章(52)
Marit ME van Bakel, Gert Printzen, Bendicht Wermuth, Ulrich N Wiesmann, Antioxidant and thyroid hormone status in selenium-deficient phenylketonuric and hyperphenylalaninemic patients The American Journal of Clinical Nutrition. ,vol. 72, pp. 976- 981 ,(2000) , 10.1093/AJCN/72.4.976
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Denise M. Ney, Angela K. Hull, Sandra C. van Calcar, Xiaowen Liu, Mark R. Etzel, Dietary Glycomacropeptide Supports Growth and Reduces the Concentrations of Phenylalanine in Plasma and Brain in a Murine Model of Phenylketonuria Journal of Nutrition. ,vol. 138, pp. 316- 322 ,(2008) , 10.1093/JN/138.2.316
J. Weglage, J. Fromm, A. van Teeffelen-Heithoff, H.E. Möller, B. Koletzko, T. Marquardt, F. Rutsch, R. Feldmann, Neurocognitive functioning in adults with phenylketonuria: Results of a long term study Molecular Genetics and Metabolism. ,vol. 110, ,(2013) , 10.1016/J.YMGME.2013.08.013
Zsolt Radak, Shuzo Kumagai, Albert W. Taylor, Hisashi Naito, Sataro Goto, Effects of exercise on brain function: role of free radicals Applied Physiology, Nutrition, and Metabolism. ,vol. 32, pp. 942- 946 ,(2007) , 10.1139/H07-081
Carolina G. Fernandes, Guilhian Leipnitz, Bianca Seminotti, Alexandre U. Amaral, Ângela Zanatta, Carmen R. Vargas, Carlos S. Dutra Filho, Moacir Wajner, Experimental evidence that phenylalanine provokes oxidative stress in hippocampus and cerebral cortex of developing rats. Cellular and Molecular Neurobiology. ,vol. 30, pp. 317- 326 ,(2010) , 10.1007/S10571-009-9455-6
P.J. Clark, W.J. Brzezinska, M.W. Thomas, N.A. Ryzhenko, S.A. Toshkov, J.S. Rhodes, Intact neurogenesis is required for benefits of exercise on spatial memory but not motor performance or contextual fear conditioning in C57BL/6J mice. Neuroscience. ,vol. 155, pp. 1048- 1058 ,(2008) , 10.1016/J.NEUROSCIENCE.2008.06.051
P. Piscopo, A. Crestini, A. Adduci, A. Ferrante, M. Massari, P. Popoli, N. Vanacore, A. Confaloni, Altered oxidative stress profile in the cortex of mice fed an enriched branched-chain amino acids diet: Possible link with amyotrophic lateral sclerosis? Journal of Neuroscience Research. ,vol. 89, pp. 1276- 1283 ,(2011) , 10.1002/JNR.22655
Angela Sitta, Vanusa Manfredini, Lidiana Biasi, Roberta Treméa, Ida V.D. Schwartz, Moacir Wajner, Carmen R. Vargas, Evidence that DNA damage is associated to phenylalanine blood levels in leukocytes from phenylketonuric patients. Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 679, pp. 13- 16 ,(2009) , 10.1016/J.MRGENTOX.2009.07.013
Tarsila Barros Moraes, Giovana Reche Dalazen, Carlos Eduardo Jacques, Raylane Silva de Freitas, Andrea Pereira Rosa, Carlos Severo Dutra-Filho, Glutathione metabolism enzymes in brain and liver of hyperphenylalaninemic rats and the effect of lipoic acid treatment Metabolic Brain Disease. ,vol. 29, pp. 609- 615 ,(2014) , 10.1007/S11011-014-9491-X