Elevated vascular endothelial growth factor in systemic sclerosis.

摘要: OBJECTIVE: To determine the serum levels of vascular endothelial growth factor (VEGF) in patients with systemic sclerosis (SSc) and to search for relationships between its clinical manifestations. METHODS: Serum VEGF SSc healthy controls were determined by ELISA. At time blood sampling, individual organ involvement was assessed, a video microscope PC based image processing used visualize nailfold capillaries quantify capillary density. RESULTS: 48 significantly higher than 30 (432 +/- 356 vs 91 64 pg/ml; p < 0.001). Patients diffuse cutaneous (n = 21) had those limited 27) 135 127 correlated well extent skin sclerosis, as modified Rodnan score (r 0.656, 0.001) TGF-beta 0.530, In particular, inversely density -0.649, However, no significant differences found without. CONCLUSION: The may contribute elevation high serve surrogate indicator damage SSc.