COVID-19 - Considerations for the paediatric rheumatologist.

作者: Christian M. Hedrich

DOI: 10.1016/J.CLIM.2020.108420

关键词:

摘要: The novel coronavirus SARS-CoV2 is a threat to the health and well-being of millions lifes across globe. A significant proportion adult patients require hospitalisation may develop severe life-threatening complications. Children, on other hand, can carry transmit virus, but usually do not disease. Mortality in paediatric age-group relatively low. Differences virus containment clearance, as well reduced inflammation-related tissue organ damage be caused by age-specific environmental host factors. Since complications adults are frequently uncontrolled immune responses resulting "cytokine storm" that controlled targeted blockade cytokines, previously established treatment with immunosuppressive treatments indeed protect children from

参考文章(25)
Yumiko Imai, Keiji Kuba, Shuan Rao, Yi Huan, Feng Guo, Bin Guan, Peng Yang, Renu Sarao, Teiji Wada, Howard Leong-Poi, Michael A. Crackower, Akiyoshi Fukamizu, Chi-Chung Hui, Lutz Hein, Stefan Uhlig, Arthur S. Slutsky, Chengyu Jiang, Josef M. Penninger, Angiotensin-converting enzyme 2 protects from severe acute lung failure Nature. ,vol. 436, pp. 112- 116 ,(2005) , 10.1038/NATURE03712
Ayato Takada, Yoshihiro Kawaoka, Antibody-dependent enhancement of viral infection: molecular mechanisms and in vivo implications Reviews in Medical Virology. ,vol. 13, pp. 387- 398 ,(2003) , 10.1002/RMV.405
Ajai A. Dandekar, Stanley Perlman, Immunopathogenesis of coronavirus infections: implications for SARS Nature Reviews Immunology. ,vol. 5, pp. 917- 927 ,(2005) , 10.1038/NRI1732
I Hamming, W Timens, MLC Bulthuis, AT Lely, GJ Navis, H van Goor, Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis The Journal of Pathology. ,vol. 203, pp. 631- 637 ,(2004) , 10.1002/PATH.1570
A. Katharina Simon, Georg A. Hollander, Andrew McMichael, Evolution of the immune system in humans from infancy to old age. Proceedings of The Royal Society B: Biological Sciences. ,vol. 282, pp. 20143085- 20143085 ,(2015) , 10.1098/RSPB.2014.3085
Emmie de Wit, Neeltje van Doremalen, Darryl Falzarano, Vincent J. Munster, SARS and MERS: recent insights into emerging coronaviruses Nature Reviews Microbiology. ,vol. 14, pp. 523- 534 ,(2016) , 10.1038/NRMICRO.2016.81
E. Kindler, V. Thiel, F. Weber, Interaction of SARS and MERS Coronaviruses with the Antiviral Interferon Response. Advances in Virus Research. ,vol. 96, pp. 219- 243 ,(2016) , 10.1016/BS.AIVIR.2016.08.006
Georgia K. Atkin-Smith, Mubing Duan, Weisan Chen, Ivan K. H. Poon, The induction and consequences of Influenza A virus-induced cell death Cell Death and Disease. ,vol. 9, pp. 1002- 1002 ,(2018) , 10.1038/S41419-018-1035-6
Mathias Uhlen, Max J. Karlsson, Wen Zhong, Abdellah Tebani, Christian Pou, Jaromir Mikes, Tadepally Lakshmikanth, Björn Forsström, Fredrik Edfors, Jacob Odeberg, Adil Mardinoglu, Cheng Zhang, Kalle von Feilitzen, Jan Mulder, Evelina Sjöstedt, Andreas Hober, Per Oksvold, Martin Zwahlen, Fredrik Ponten, Cecilia Lindskog, Åsa Sivertsson, Linn Fagerberg, Petter Brodin, A genome-wide transcriptomic analysis of protein-coding genes in human blood cells Science. ,vol. 366, ,(2019) , 10.1126/SCIENCE.AAX9198
Chaolin Huang, Yeming Wang, Xingwang Li, Lili Ren, Jianping Zhao, Yi Hu, Li Zhang, Guohui Fan, Jiuyang Xu, Xiaoying Gu, Zhenshun Cheng, Ting Yu, Jiaan Xia, Yuan Wei, Wenjuan Wu, Xuelei Xie, Wen Yin, Hui Li, Min Liu, Yan Xiao, Hong Gao, Li Guo, Jungang Xie, Guangfa Wang, Rongmeng Jiang, Zhancheng Gao, Qi Jin, Jianwei Wang, Bin Cao, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China The Lancet. ,vol. 395, pp. 497- 506 ,(2020) , 10.1016/S0140-6736(20)30183-5