Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection

作者: S. A. Shabalina , L. Y. Yampolsky , A. S. Kondrashov

DOI: 10.1073/PNAS.94.24.13034

关键词:

摘要: The parameters of the spontaneous deleterious mutation process remain poorly known, despite their importance. Here, we report results a accumulation experiment performed on panmictic populations Drosophila melanogaster without any genetic manipulations. Two experimental were kept for 30 generations under relaxed natural selection. Each generation, 100 pairs formed randomly, and every fecund pair contributed son daughter to next generation. Comparison with two controls, one cryopreserved other as but long generation time, showed that number surviving offspring per female declined by 0.2% 2.0% benign harsh, competitive conditions, respectively. Thus, mutational pressure fitness may be strong depends critically conditions which is assayed.

参考文章(29)
Terumi Mukai, Sadao I Chigusa, L E Mettler, James F Crow, Mutation Rate and Dominance of Genes Affecting Viability in DROSOPHILA MELANOGASTER Genetics. ,vol. 72, pp. 335- 355 ,(1972) , 10.1093/GENETICS/72.2.335
Michael Lynch, Hong Wen Deng, Estimation of Deleterious-Mutation Parameters in Natural Populations Genetics. ,vol. 144, pp. 349- 360 ,(1996) , 10.1093/GENETICS/144.1.349
David Houle, Michael Lynch, Bob Morikawa, Comparing Mutational Variabilities Genetics. ,vol. 143, pp. 1467- 1483 ,(1996) , 10.1093/GENETICS/143.3.1467
Jeff E. Engel, Chun-Fang Wu, Altered habituation of an identified escape circuit in Drosophila memory mutants. The Journal of Neuroscience. ,vol. 16, pp. 3486- 3499 ,(1996) , 10.1523/JNEUROSCI.16-10-03486.1996
Peter D. Keightley, Nature of deleterious mutation load in Drosophila. Genetics. ,vol. 144, pp. 1993- 1999 ,(1996) , 10.1093/GENETICS/144.4.1993
Suzanne C. Borlase, David A. Loebel, Richard Frankham, Roderick K. Nurthen, David A. Briscoe, Grant E. Daggard, Modeling Problems in Conservation Genetics Using Captive Drosophila Populations: Consequences of Equalization of Family Sizes Conservation Biology. ,vol. 7, pp. 122- 131 ,(1993) , 10.1046/J.1523-1739.1993.07010122.X
Laurence D. Hurst, Joel R. Peck, Recent advances in understanding of the evolution and maintenance of sex. Trends in Ecology and Evolution. ,vol. 11, pp. 46- 52 ,(1996) , 10.1016/0169-5347(96)81041-X
Brian Charlesworth, Background selection and patterns of genetic diversity in Drosophila melanogaster. Genetics Research. ,vol. 68, pp. 131- 149 ,(1996) , 10.1017/S0016672300034029
D. Houle, D. K. Hoffmaster, S. Assimacopoulos, B. Charlesworth, The genomic mutation rate for fitness in Drosophila Nature. ,vol. 359, pp. 58- 60 ,(1992) , 10.1038/359058A0