In Vivo Tropisms and Kinetics of Rat Theilovirus Infection in Immunocompetent and Immunodeficient Rats

摘要: Rat theilovirus (RTV) is a cardiovirus related to Theiler's murine encephalomyelitis virus. While RTV prevalent viral pathogen of rats used in biomedical research, the pathogenesis and characterization infections not well understood. In studies reported herein, we immunohistochemistry identify antigens enterocytes small intestines Sprague–Dawley (SD) rats. Fecal shedding immunocompromised immunocompetent following oral gavage with RTV1 was high for first 2 weeks infection persistent loads being observed nude but also detected mesenteric lymph nodes spleen addition, magnitude serum antibody responses differed between rat strains Brown Norway SD having significantly higher response than CD or Fischer 344 These data suggest that has tropism epithelial cells intestine, have differing infection, sustained fecal extraintestinal dissemination occurs deficient T cell-dependent adaptive immunity. merit as model further exposure.