Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease.

摘要: It is now well established, at least in animal models, that exercise elicits potent pro-cognitive and pro-neurogenic effects. Alzheimer's disease (AD) one of the leading causes dementia represents greatest burdens on healthcare systems worldwide, with no effective treatment for to date. Exercise presents a promising non-pharmacological option potentially delay onset or slow down progression AD. interventions mouse models AD have been explored found reduce amyloid pathology improve cognitive function. More recent studies expanded research question by investigating potential anti-inflammatory effects exercise. In this review we summarise examined exercise-mediated pathology, function, hippocampal neurogenesis neuroinflammation transgenic Furthermore, attempt identify optimum conditions required elicit benefits, taking into account age model, as type duration