Elucidation of the Streptomyces coelicolor pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde, an intermediate in prodiginine biosynthesis.
作者： Anna E. Stanley , Laura J. Walton , Malek Kourdi Zerikly , Christophe Corre , Gregory L. Challis
DOI: 10.1039/B609556A
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摘要: The biosynthetic pathway to 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC), a key intermediate in the biosynthesis of prodiginine antibiotics Streptomyces coelicolor, has been elucidated using combination gene replacements and feeding experiments with chemically synthesised MBC synthetic analogue intermediate.
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