A community trial of ivermectin in the onchocerciasis focus of Asubende, Ghana. I. Effect on the microfilarial reservoir and the transmission of Onchocerca volvulus.

摘要: A community trial of the microfilaricide ivermectin was undertaken in an isolated focus hyperendemic savanna onchocerciasis Ghana. One objectives to determine effect mass treatment on microfilarial reservoir and transmission Onchocerciasis volvulus. Since 1978 has been under entomological surveillance. This intensified from 1 September 1987 till 11 February 1988 with daily vector collection dissection over 30,000 flies. total 14,991 people were treated 7-10 October 1987. Skin snip surveys done pre-treatment, at two four months after treatment. The mean skin load persons had fallen by more than 96% During next there increase microfilaria loads which appeared be faster reported clinical trials. microfilariae available for reduced estimated 68%-78% consistent results indicated a reduction 65%-85% during first three post-treatment months. present study shown time that chemotherapy can significantly reduce transmission. However, remaining level still unacceptably high further studies are required predict long term impact repeated