Secalonic acid D reduced the percentage of side populations by down-regulating the expression of ABCG2
作者： Ya-peng Hu , Li-yang Tao , Fang Wang , Jian-ye Zhang , Yong-ju Liang
DOI: 10.1016/J.BCP.2013.04.003
关键词:
摘要: The side population cells characterized by the ability to transport Hoechst 33342 out of have been identified as cancer stem-like cells. ABCG2 is found confer (SP) phenotype, multidrug resistance (MDR) and tumor recurrence. In this study, we secalonic acid D (SAD), a metabolite marine-derived mangrove endophytic fungus, showed potent anticancer effect on ABCB1-, ABCC1- ABCG2- overexpressing MTT assay. Furthermore, SAD could down-regulate expression decrease percentage SP in lung assay sorted were sensitive also inhibit sphere-forming Although did not affect mRNA, it shortened half-life protein activating calpain 1. These results implicated that be developed leading compound target stem would promising agent treat patients.
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