Analgesic and anti-inflammatory activities of 18-acetoxy-ent-kaur-16-ene from Annona squamosa L. bark

作者: M. J. Chavan , P. S. Wakte , D. B. Shinde

DOI: 10.1007/S10787-010-0061-5

关键词:

摘要: The Annona squamosa L. bark was collected from Ahmednagar district, India. 18-Acetoxy-ent-kaur-16-ene isolated petroleum ether extract (PE) and studied for its analgesic anti-inflammatory activities. at the doses of 12.5 25 mg/kg, PE a dose 50 mg/kg exhibited significant along with activity.

参考文章(14)
Tsang-Hsiung Yang, Chi-Ming Chen, Structure of Squamolone, a Novel Diazepine from Anona Squamosa L Journal of The Chinese Chemical Society. ,vol. 19, pp. 149- 151 ,(1972) , 10.1002/JCCS.197200021
Luciana C Block, Adair RS Santos, Márcia Maria de Souza, Cristiano Scheidt, Rosendo A Yunes, Mário Alves Santos, Franco Delle Monache, Valdir Cechinel Filho, None, Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa. Journal of Ethnopharmacology. ,vol. 61, pp. 85- 89 ,(1998) , 10.1016/S0378-8741(98)00019-1
S. Vohora, Ishwar Kumar, S. Naqvi, Phytochemical, pharmacological, antibacterial and anti-ovulatory studies on Annona squamosa. Planta Medica. ,vol. 28, pp. 97- 100 ,(1975) , 10.1055/S-0028-1097835
C. A. Winter, E. A. Risley, G. W. Nuss, Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs Experimental Biology and Medicine. ,vol. 111, pp. 544- 547 ,(1962) , 10.3181/00379727-111-27849
X.-H. Li, Y.-H. Hui, J. K. Rupprecht, Y.-M. Liu, K. V. Wood, D. L. Smith, C.-J. Chang, J. L. McLaughlin, Bullatacin, bullatacinone, and squamone, a new bioactive acetogenin, from the bark of Annona squamosa. Journal of Natural Products. ,vol. 53, pp. 81- 86 ,(1990) , 10.1021/NP50067A010
H. Wagner, M. Reiter, W. Ferstl, Neue herzwirksame Drogen Planta Medica. ,vol. 40, pp. 77- 85 ,(1980) , 10.1055/S-2008-1074944
PEARL CRUNKHORN, S. C. R. MEACOCK, Mediators of the inflammation induced in the rat paw by carrageenin. British Journal of Pharmacology. ,vol. 42, pp. 392- 402 ,(1971) , 10.1111/J.1476-5381.1971.TB07124.X
C. R. Chapman, K. L. Casey, R. Dubner, K. M. Foley, R. H. Gracely, A. E. Reading, Pain measurement: an overview Pain. ,vol. 22, pp. 1- 31 ,(1985) , 10.1016/0304-3959(85)90145-9
Hee-Juhn Park, In-Tae Kim, Jong-Heon Won, Seoung-Hee Jeong, Eun-Young Park, Jung-Hwan Nam, Jongwon Choi, Kyung-Tae Lee, Anti-inflammatory activities of ent-16αH,17-hydroxy-kauran-19-oic acid isolated from the roots of Siegesbeckia pubescens are due to the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB inactivation European Journal of Pharmacology. ,vol. 558, pp. 185- 193 ,(2007) , 10.1016/J.EJPHAR.2006.11.036
A. Mishra, J. Dogra, J. Singh, O. Jha, Post-coital antifertility activity of Annona squamosa and Ipomoea fistulosa. Planta Medica. ,vol. 35, pp. 283- 285 ,(1979) , 10.1055/S-0028-1097218