The Fabrication of Poly( Σ -caprolactone)-Poly(ethylene oxide) Sandwich Type Nanofibers Containing Sericin-Capped Silver Nanoparticles as an Antibacterial Wound Dressing.

摘要: In this study, antibacterial, synthetic poly(Σ-caprolactone)-poly(ethylene oxide) (PCL-PEO) multilayer nanofibers were produced by an electrospinning method. The material was synthesized in 3 layers. upper-lower protective layers PCL and the intermediate layer from PEO nanofiber containing sericin-capped silver nanoparticles (S-AgNPs). conditions which nano-sized, smooth, bead-free fibers obtained determined to be applied voltage of 20 kV, a flow rate 8 μL/min distance between collector needle tip 22 cm for (dissolved at 12% g/mL concentration chloroform:methanol (3:2) solvent mixture) layer. For S-AgNPs doped 3.5% water), corresponding 15 cm. To characterize three-layer that consisted layers, FTIR SEM analyses performed, water retention capacity, situ degradability antibacterial activity investigated. According analysis, found smooth average size forming 687 nm while 98 nm. Antibacterial tests performed using gram-positive (Staphylococcus aureus ATCC 6538) gram-negative (Escherichia coli 25922) bacteria resulting biomaterial have antimicrobial effect on both bacteria. It 3-layer study can used as wound dressing.