Conditional over-expression of RAGE by embryonic alveolar epithelium compromises the respiratory membrane and impairs endothelial cell differentiation.
作者： Duane R Winden , Nicholas T Ferguson , Benjamin R Bukey , Alexander J Geyer , Alex J Wright
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摘要: Background Receptors for advanced glycation end-products (RAGE) are cell surface receptors prominently expressed by lung epithelium. Previous research demonstrated that over-expression of RAGE murine alveolar epithelial cells during embryogenesis caused severe hypoplasia and neonatal lethality. However, the effects on adjacent matrix endothelial remained unknown.
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