Analysis of right and left ventricular performance of the rat heart with chronic myocardial infarction.

摘要: 1. The rat heart develops a compensatory hypertrophy after infarction which is secondary to volume overload in the left ventricle (LV) and pressure right (RV). This study was undertaken determine whether reduced inotropic response Ca2+ presented by LV of infarcted rats extends RV this hemodynamic profile vivo affects contractile performance ventricles assessed vitro. 2. Male adult were submitted coronary artery ligation produce (Inf) or sham surgery (SO) used 4 5 weeks later. data recorded anesthetized animals systolic both evaluated vitro hearts perfused Langendorff technique. isovolumic (ISP) developed measured at various diastolic pressures (0 30 mmHg) concentrations (0.62, 1.25, 2.50 mM). 3. higher Inf (N = 12) than SO (42 +/- vs 26 1 mmHg, P < 0.05). A positive linear correlation (r 0.86, 0.01) between weight body ratio observed. 4. Length-dependent activation, using normalized ventricular function curves, unchanged hearts. In LV, however, slight improvement observed relation for 15 mmHg. 5. similar depression Moreover, increase ISP flattened lower group. 6. present results demonstrate that depresses ventricles. may contribute capacity generate external work under conditions metabolic demand.