Serial angiographic and intravascular ultrasound evaluation to interrogate the presence of late “catch-up” phenomenon after cypher® sirolimus-eluting stent implantation

摘要: Despite the expressive reduction in intimal hyperplasia (IH) formation after DES implantation at mid-term, late restenosis has been recently noticed. Our objective was to determine, by means of serial angiography (QCA) and intravascular ultrasound (IVUS) two different time points, whether occurrence “late catch-up” phenomenon occurs sirolimus-eluting stent (SES) implantation. Thirty-eight non-complex patients treated with a single 18-mm SES who had systematic QCA IVUS analyses mean 8 20 months were enrolled. Primary endpoint is evaluate temporal course IH implantation, comparing in-stent loss percent obstruction between invasive follow-ups. Mean cohort age 59.3 years 31.6% diabetics. Baseline reference vessel diameter 2.8 ± 0.4 mm lesion length 11.5 3.5 mm. Left anterior descending artery most frequent target (55.3%). Between months, non-significant increase from 0.10 0.18 0.15 0.30 (P = 0.38) observed. By IVUS, slight (1.03 2.13 1.76 1.87%, P 0.12) detected evaluations. Interestingly, all neoformed tissue accrued accumulated distal portion stent. In scenario, associated minimal, volume months.