Cellular growth in various regions of the developing rat brain.

摘要: Extract: The cellular growth patterns in whole brain, cerebrum, cerebellum, hippocampus, and brainstem were examined rats between 6 22 days of age. When weight alone was measured, little difference seen the various regions; however, when cell number (DNA) or protein per (protein: DNA) regional differences became very striking. In DNA content increased 8.5 fold 17 subsequently tapered off. protein: ratio declined during this period. Although increase cerebrum only 2.5 fold, it continued until 21 days, at which time experiment terminated. After 10 there also an ratio. brainstem, a modest 14 days. 4 fold. discrete These data demonstrate existence distinct postnatal maturation rat brain. Speculation: although often viewed as organ, is composed anatomically regions that perform separate unique functions. Previous from laboratory have shown division ceases brain by postnatally human six months This study demonstrates different rates entire pattern regionally specific. Since certain functions are controlled, possible described here functional correlates. Alteration environment (nutrition) known to affect rate It environmental effects may be By studying stimuli (anoxia malnutrition) on correlating these with changes, relate changes deficits.