Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the cat
作者： Lars Edvinsson , Bertil B. Fredholm , Edith Hamel , Inger Jansen , Catherine Verrecchia
DOI: 10.1016/0304-3940(85)90166-1
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摘要: Abstract Calcitonin gene-related peptide (CGRP), substance P (SP) and vasoactive intestinal polypeptide (VIP) have been proposed to be neurotransmitters/neuromodulators in cerebral perivascular nerve fibers. Here, we present pharmacological biochemical evidence showing that these peptides different modes of relaxing blood vessels the cat. CGRP causes pronounced relaxation, this occurs simultaneously with stimulation cyclic adenosine monophosphate (cAMP) accumulation. The strong VIP-induced dilatation is parallelled by cAMP accumulation, albeit a lower magnitude than CGRP. SP-induced relaxation was much weaker VIP, it not associated Only at concentrations SP where maximum had occurred, non-significant accumulation seen. responses acetylcholine were absent arteries endothelium removed, whereas relaxations induced VIP persisted.
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