Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life.

摘要: Hypertension originates from early-life insults by so-called “developmental origins of health and disease” (DOHaD). Studies performed in the previous few decades indicate that fructose consumption is associated with an increase hypertension rate. It emerging field tends to unfold nutrient–gene interactions maternal high-fructose (HF) intake on offspring which links renal programming programmed hypertension. Reprogramming interventions counteract disturbed induced HF exert protective effects against developmentally Here, we review key themes effect transcriptome changes We have particularly focused following areas: metabolic kidney disease; development adult offspring; changes; application reprogramming prevent consumption-induced animal models. Provision personalized nutrition still a faraway goal. Therefore, there urgent need understand develop effective strategies for treating other consumption-related diseases.