Reduction-responsive modification-induced higher efficiency for attenuation of tumor metastasis of low molecular weight heparin functionalized liposomes
作者： Jilai Tian , Miaomiao Han , Yue Wang , Kang Qian , Xue Ke
DOI: 10.1039/C5RA27227K
关键词:
摘要: For oncotherapy, a delivery system that can effectively prevent and attenuate tumor metastasis is greatly desirable. Herein, we report novel of liposomal doxorubicin with reduction-responsive modification low molecular weight heparin (LMWH) to realize higher efficacy in the prevention metastasis. A series DOX formulations crude DOX-Lip, reduction-insensitive LMWH-DOX-Lip LMWH-ss-DOX-Lip were prepared. The liposomes LMWH chains resulted cellular uptake, cytotoxicity anti-invasion anti-migration abilities compared liposomes, owing fast release cytoplasm. Meanwhile, evaluation heparanase expression was also adopted reveal possible underlying mechanism effects on attenuation In vivo pulmonary melanoma assays confirmed enhanced drug lower side DOX-Lip or control group. These results may be attributed rational design carriers synergistic combination moieties loaded via modification.
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